Flexible In Vitro Culture System for
Species-Relevant Outcomes
Modern research demands accurate in vitro to in vivo extrapolation. However, fixed media formulations in standard systems limit the ability to accommodate multiple species.
TruVivo Flex puts the power of customization in your hands, enabling you to tailor supplementation concentrations to address your species-specific culture requirements and deliver more predictive outcomes in T4 metabolism and clearance via glucuronidation pathways.
Download our Data Sheet to see demonstrated, stable function and T4 clearance data in both rat and human hepatocytes.
Solving Inter-Species Limitations:
The Future of Chemical Risk Assessment Is Here
TruVivo Flex redefines thyroid disruption testing with a validated, glucocorticoid-free system enabling parallel T4 clearance assessment in human and rat hepatocytes. This single platform provides mechanistic insight and IVIVE translation, accelerating decision-making while reducing animal testing.
Modular, flexible in vitro hepatic system
Our easy-to-use kit provides human feeder cells, supplements, and glucocorticoid-free media- enabling precise control over formulations to accommodate species-specific requirements.
Perform assays in your lab, or ours
TruVivo Flex is available as a kit or through LifeNet Health LifeSciences In Vitro Assay Services
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Translatable results across species
TruVivo Flex is validated for use with rat hepatocytes, with a framework adaptable for future applications of additional species. Early adoption and validation by leading agrochemical companies highlight TruVivo Flex’s promise in addressing unmet needs and supporting future regulatory alignment for endocrine-disrupting compounds.
The TruVivo Flex Advantage
Discover how TruVivo Flex merges proven performance with the adaptability essential for the extrapolation from in vitro insights to in vivo predictions in your preclinical workflow.
- Flexibility: Tailored supplementation based on species and study requirements (i.e, glucocorticoid levels)
- Validated Success: Demonstrated effectiveness in rat hepatocyte T4 metabolism and glucuronidation assays, providing confidence in predicting species-specific responses
- Ease-of-Use: No specialized equipment required and only standard cell culture skills needed
- Reproducibility: Generate consistent, reliable results across human and rat studies
- Reliability: Built on the established TruVivo system's proven performance, maintaining cellular functionality and metabolic activity over extended periods
Application Spotlight: Agrochemical Programs
Thyroid Hormone Clearance Assays
Evaluating T4 glucuronidation in rat and human hepatocytes
Chronic Exposure Studies
Support long-term culture needs with ≥2 weeks of hepatocyte function
Comparative Metabolism Research
Bridge inter-species variations in enzyme induction between rat and human models
Try TruVivo Flex
What's in the kit
The TruVivo Flex kit includes prequalified primary human feeder cells, and glucocorticoid-free media, that when properly supplemented is optimized to support at least two weeks of culture.
How TruVivo Flex is shipped
Same- or next-day shipping is offered to most locations worldwide. Cells are shipped in the vapor phase of liquid nitrogen. Media components are shipped on dry ice or refrigerated cold packs.
What can be ordered
Available in 24-well and 96-well formats, TruVivo Flex requires seperate purchase of LifeNet Health's TruVivo-qualified human hepatocytes or rat hepatocytes from your preferred vendor.
What to expect
Users will receive easy-to-follow instructions and personalized support. Our scientific team can help with everything from initial training and lot selection to troubleshooting.