**Advancing Thyroid Toxicity Assessment with Human-Relevant In Vitro Models**

Discover how in vitro hepatocyte models and quantitative in vitro to in vivo extrapolation (QIVIVE) can refine thyroid toxicity assessment, reduce animal testing, and support next-generation risk assessment (NGRA). In this session, Beas Bhattacharya, PhD, Global Regulatory Toxicologist at Corteva Agriscience, compares two hepatocyte models to evaluate liver-mediated thyroid hormone clearance in rats, helping define species-specific mechanisms and strengthen human relevance.

Key Takeaways:

Understand species-specific differences in thyroid hormone clearance.
Learn how NAM-based hepatocyte models inform next-generation risk assessment (NGRA).
Explore how QIVIVE supports mechanistic linkage between in vitro data and in vivo outcomes.
See how these tools can derisk discovery molecules and refine thyroid toxicity prediction.

Beas Bhattacharya earned her bachelor’s degree in Electronics and Communication Engineering in India before pursuing her passion for biological sciences. She completed her Ph.D. in Toxicology at Indiana University Bloomington, where her research focused on understanding the effects of vaping liquids on zebrafish embryonic development. Following her doctoral work, Beas joined Corteva Agriscience as a Postdoctoral Research Fellow, investigating thyroid toxicity using zebrafish and TruVivo hepatocyte models. Currently, Beas serves as a Global Regulatory Toxicologist at Corteva, where she supports the registration of products worldwide across both seeds and crop protection portfolios. Her role involves ensuring compliance with global regulatory standards and contributing to the safe and sustainable use of agricultural solutions.