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The International Society for the Study of Xenobiotics (ISSX) is a global organization dedicated to advancing the science of drug metabolism, pharmacokinetics, and toxicology.
Discover LifeNet Health LifeSciences' high-quality, human-based in vitro solutions that help empower scientists to advance ADME, DMPK, and translational research. Our products and services deliver physiologically relevant data to improve predictability, support in vitro to in vivo extrapolation, and can accelerate the development of safer, more effective therapies. By providing consistent, reliable models and expertise, our solutions can help researchers bridge critical gaps between discovery and clinical outcomes.
Human-Relevant In Vitro Solutions to Accelerate ADME and Translational Research
Leverage LifeNet Health's human cells and in vitro models, research biospecimens, and cell-based assay services to advance your research.
Cells & Cell Models
- Human Hepatocytes and Liver NPCs
- TruVivo 2D+ Hepatic System
- 3D Thyroid Microtissues
Assay Services
- DMPK/ADME in vitro assays
- New Approach Methodologies (NAMs)
- TruVivo Services
Research Biospecimens
- Brain, Skin, Gut, and More
- Healthy and Diseased
- Prospective Samples
Featured Products
TruVivo
TruVivo is the first and only 2D+ hepatic system to provide human-relevant, reliable results in an easy-to-use format. With TruVivo, users can expect the simplicity and flexibility of a 2D model, along with the relevance, longevity, architectural integrity, and robustness of a 3D model.
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TruVivo Flex
An extension of our proven TruVivo system, TruVivo Flex offers customizable glucocorticoid media supplementation that supports both human and rat hepatocytes, merging proven performance with the adaptability essential for the extrapolation from in vitro insights to in vivo predictions.
Primary Human Hepatocytes & Non-Parenchymal Liver Cells
We offer primary human hepatocytes and non-parenchymal liver cells. including Kupffer cells, stellate cells, and liver endothelial cells. Our large inventory of primary human hepatocytes is available in plateable and suspension categories. Hepatocytes are tested for phase I and II enzyme activity as well as the induction of CYP3A4, CYP2B6, and CYP1A2 mRNA and specific activity. Donor-matched cells are available, and cells span the MAFLD/MASH disease spectrum.
Scientific Presentations
Poster Presentation: Morphology and functionality of primary rodent hepatocytes in TruVivo® Flex.
Presenter: Justin Odanga
Date & Time: Monday, September 22nd; 1:30 - 2:15 pm
Poster Session 1
Poster # P41
Discover how TruVivo Flex now maintains rat hepatocytes with consistent albumin and urea production for at least two weeks. These data highlight TruVivo's potential for directly comparing metabolism, clearance, and toxicity between rat and human species on a single platform.
Key Takeaways:
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Stable, Long-Term Hepatic Function: TruVivo Flex maintains consistent albumin and urea production for 14 days in rat hepatocytes, without requiring Matrigel, improving reproducibility and reducing workflow variability.
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Enables Species-Relevant Metabolism Studies: Demonstrates robust CYP3A23 induction in multiple rodent hepatocyte strains, supporting more predictive rodent based metabolic assessments for early-stage compound screening.
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Reproducible and Ethical Testing Platform: Offers a reliable in vitro alternative for preclinical research, aligning with industry efforts to reduce animal use through scalable, species-relevant, and reproducible systems.
Meet Our Team
Edward LeCluyse, PhD
Research Fellow
Dr. Edward LeCluyse received his Ph.D. in Biochemistry at the University of Kansas and did his post-doctoral training in Pharmacology and Toxicology at the University of Kansas Medical School. He has over 35 years of experience in basic research and in vitro translational model development in industry, biotech, and academia. Dr. LeCluyse has done extensive research, development, and implementation of novel in vitro human hepatic model systems to study mechanisms of liver metabolism, DILI, and disease.
Paul Gallant
Global Sales Director
Paul has more than 20 years of experience as a leading executive and scientist in entrepreneurial biotechnology companies and large pharmaceutical companies. As Global Sales director, Paul engages with customers in study design, method development and all-human sourcing in the US, Europe, Japan, and China.
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Dawn Stricker
LifeSciences Area Sales Director
Dawn is a highly accomplished biotechnology executive with over 20 years of global experience in sales, marketing management, and strategic leadership. She brings deep expertise in biological specimens, primary cells, and biobanks across sectors such as immuno-oncology, Next-Gen, AI, ADME, and cell and gene therapy, with a proven track record of building high-performing teams and driving consistent revenue growth.
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Rachel Whisnant
Account Executive
Rachel Whisnant is a sales executive specializing in preclinical drug development, with a passion for advancing research through hepatocyte and hepatic models. As both a business professional and patient advocate, she is dedicated to supporting innovations that improve scientific outcomes and patient lives.
Justin Odanga
Translational Scientist
Justin Odanga is a seasoned scientist specializing in primary cell biology and advanced model systems, with deep expertise in in vitro assay design, optimization, and translational research. With a strong background in biotech and pharma, he combines technical excellence in techniques such as flow cytometry, ELISA, and primary cell culture with a passion for innovation, collaboration, and community leadership.
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Lindsey Whaley
Senior Product Manager
In her role as Senior Product Manager for LifeNet Health LifeSciences, Lindsey collaborates with cross-functional teams to manage new product releases and an existing portfolio in a global market. Known for her collaborative approach and ability to translate marketing insights into actionable strategies, Lindsey is dedicated to delivering products that align with core customer needs.
